With the rapid development of life sciences, pharmaceutical research and development, small molecule research, virtual simulation and other fields, digital medicine has also been gradually approaching. Although digital medicine is still immature, the digitalization of medicine is unstoppable. One day, it will become the mainstream of medicine.

When it comes to the development of medicine, additive manufacturing (3D printing for short) has to be promoted. 3D printing is an emerging manufacturing technology that builds up materials layer by layer to produce physical objects based on digital models. It has significant advantages in personalized customization, complex structural component preparation, etc. It has an important impact on the entire manufacturing industry chain and is a typical disruptive technology in the manufacturing industry.

Problems encountered with 3D medical printing technology
 

At present, 3D bioprinting has crossed the first and second stages, and has spawned an industrial chain prototype in medical models, diagnostic equipment, rehabilitation aids, prosthetics, teeth and artificial joints.

There have been more than 100,000 post-operative evaluation results of 3D printed hip implants in the North American market. It has been realized that each patient is tailored and an individualized treatment plan is developed, which will allow patients to obtain the greatest benefit.

However, 3D bioprinting still has several technical limitations:

Need for more functional, cell-friendly bioinks for printing;

Better technology and printers are needed to manufacture models with high survival rate and high precision;

Faster and stronger cross-linking agents are required to ensure the integrity and stability of the printed body;

Longer-term physiological simulation systems need to be fabricated with the help of microfluidic technology.

The application of 3D printing technology in medical

Today, as one of the representative cutting-edge technologies, 3D printing has been recognized by many people in the industry for its application value. In the medical field, 3D printing has gradually penetrated into many sub-application scenarios, such as surgical model rehearsal, rehabilitation medical equipment manufacturing, etc. Driven by the cutting-edge technology of 3D printing, the service model of the traditional medical industry is accelerating its transformation, and the development of intelligent, efficient and professional medical service models is also accelerating.

surgical rehearsal model

Preoperative planning for high-risk, difficult surgery is critical for healthcare workers. In the previous surgical rehearsal, medical workers often needed to obtain patient data through imaging equipment such as CT and MRI, and then use software to convert 2D medical images into realistic 3D data. Now medical workers can directly print 3D models with the help of devices such as 3D printers. This not only assists doctors in accurate surgical planning and improves the success rate of surgery, but also facilitates the communication between medical workers and patients on surgical plans.

surgical guide

As an auxiliary surgical tool in the surgical process, it can help medical workers to accurately implement the surgical plan. Currently, the types of surgical guides include joint guides, spinal guides, and oral implant guides. The surgical guide made by 3D printing can make up for the shortcomings of the traditional surgical guide manufacturing process, and at the same time, the size and shape of the guide can be adjusted as needed. In this way, different patients can have guides that meet their real needs.

dental applications

The application of 3D printing in dentistry has been a hot topic in recent years. In general, the application of 3D printing in the dental field is mainly focused on the design and manufacture of metal teeth and invisible braces. The advent of cutting-edge 3D printing technology has created more possibilities for people who need orthodontic treatment to achieve personalized braces. At different stages of orthodontic treatment, orthodontists need different braces. Using 3D printing to make multiple pairs of braces for orthodontic treatment not only helps the healthy development of teeth, but also reduces the manufacturing cost of braces.

Orthopedic applications

Currently, many medical workers are using the cutting-edge technology of 3D printing to treat patients with bone injuries. By establishing an accurate three-dimensional bone physical model for a patient, medical workers can further observe the patient's bone condition and the specific parts of bone damage, and formulate corresponding treatment plans. With the technical advantages of 3D printing, a series of difficult problems in the treatment of long bone fractures and hip injuries have been gradually overcome.

skin repair

When used in the treatment of patients with severe skin burns such as fire, due to the long treatment period and obvious postoperative scars, it is difficult to achieve new improvements in the skin repair effect. For years, researchers have been trying to find new ways to improve skin repair, and the advent of cutting-edge 3D printing technology has provided new ways to repair damaged skin. By scanning damaged skin wounds, medical staff can reconstruct a three-dimensional model of the skin wound, and then use cutting-edge printing technology to print a variety of high-viscosity materials containing skin cells in situ with high precision and high activity, thereby constructing a Bionic skin structure.

biological tissue

In recent years, the scientific and medical communities have made 3D printing of biological organs and tissues one of the key research topics. At present, the tissues and organs of bio-3D printing mainly include nose, ears, blood vessels, kidneys, heart, skin, cornea, etc. Whether it is artificial blood vessels, cartilage tissue, liver tissue or kidney tissue, the core is the isolation (or directed induction) and large-scale expansion of specific types of cells. 3D printing technology, in the process of artificial tissue and organ culture, can construct the three-dimensional shape of the tissue and organ, so that the cells can grow according to the preset shape, thereby promoting the healthy development of cells and replacing the diseased tissue of the human body.

Rehabilitation medical equipment

In practical applications, rehabilitation medical devices such as prosthetics and hearing aids have small batch and customized requirements. Due to the complex design of these rehabilitation medical devices, traditional CNC machine tools are often difficult to achieve good results due to the limitations of processing angles and other factors. After using 3D printing technology, the manufacturing process of rehabilitation medical equipment has been further improved. The cost of manufacturing a single customized rehabilitation medical device is reduced, and the manufacturing cycle is further shortened.

personalized medicine

With the rapid development of smart medical care, patients are looking forward to a professional, personalized and precise medical service model. In terms of pharmacy, the use of 3D printing technology to prepare pharmaceutical sustained-release devices has many advantages. 3D printing can realize the local detail control of a variety of drug materials and precisely control the composition of a drug. For children and the elderly, scientifically controlling the dosage of drugs can also help improve the safety of medication. Through 3D printing technology and equipment, powder materials can be bonded and molded, and a porous structure with complex cavities can be realized in medical applications, which is of great significance for the release of drug effects.

In fact, the emergence of 3D printing technology has subtly changed the development process of the traditional medical industry at multiple levels. It is believed that with the continuous maturity of technology, 3D printing will give birth to a new model of better medical services, and people will also feel the convenience brought by emerging technologies to life.

Case Studies

Background of the project

Most people have gone to the hospital to take "films", but have you ever thought that these images can also be displayed in 3D? Through 3D medical images, doctors can observe the 3D structure of the target at any angle, in any size, and in any combination, and the diagnosis will be more accurate. However, 3D medical imaging requires far more data volume and performance than 2D imaging. A well-known hospital in China adopts the Blue Ocean Brain Cold Plate Water-cooled Workstation HD210 to improve access performance through technologies such as directory slicing and small file aggregation to cope with the pressure brought by the explosive growth of small files in the 3D system.

Compared with 2D images, the file capacity of 3D images is much larger. To meet the storage requirements of these 3D images, the capacity of the storage system must be large enough, and it is best to achieve agile expansion according to business needs to avoid excessive storage. The advanced storage system construction brings cost pressure. In addition, the preservation of hospital image data and the continuous operation of business are of great significance to the diagnosis and treatment of diseases. In this hospital, the upper layer is connected to the virtualization platform, and the virtual machine business cannot be interrupted. The underlying storage is required to be highly stable and reliable, and the business will not be interrupted and data will not be lost. .

Features:

The pre-trained network can be transferred to any AI application of 3D medical images, including but not limited to tasks such as segmentation, detection, and classification;

Especially suitable for small data medical imaging AI scenarios, which can speed up network convergence and improve network performance;

Fine-tuning training can be performed by simply configuring a small number of interface parameter values;

Provide multi-card training and test evaluation codes, rich interfaces and strong scalability;

Provides 3D pre-trained models of different depths, which can be used by applications of different data levels.

Main Specifications

Reliability: mean time between failures MTBF≥15000 h

Working temperature: 5~40 ℃

Working humidity: 35%~80%

Storage temperature: -40~55 ℃

Storage humidity: 20%~90%

Noise: ≤35dB

Solution advantage

In order to relieve the pressure of massive data storage brought about by the system going online, the hospital uses the Blue Ocean Brain cold plate water-cooled workstation HD210, and deploys a distributed block storage cluster to meet the hospital's growing storage capacity requirements, flexible expansion, and performance increases linearly with capacity expansion .

In addition to performance issues, business reliability is also an important concern for hospitals. The hospital adopts the Blue Ocean Brain cold plate water-cooled workstation HD210 for active-active deployment, connects to the upper-layer virtualized business, and automatically switches over after a single storage failure, ensuring that business data is not lost and the business is running stably.

Summarize

After the deployment of Blue Ocean Brain Cold Plate Water-cooled Workstation HD210, the problem of concurrent reading and writing of massive small files in the system has been solved, and the imaging system can run smoothly and stably even during peak business periods. Moreover, due to the high scalability of the Blue Ocean Brain Cold Plate Water-cooled Workstation HD210, the hospital can agilely increase capacity and performance by adding storage nodes in the process of business data growth.

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