Plasmodium can invade human red blood cells and interfere with the normal function of cells. Recently, scientists from Basel University and other places have developed a kind of micro nanostructure that can “trick” Plasmodium to imitate human cell membrane. Relevant research has been published in the international journal ACS Nano, which may help to develop new therapies and vaccines for malaria and other infectious diseases.
Wolfgang Meier, a researcher, said that the normal circulation of Plasmodium could be interrupted by using nano simulation technology. In this paper, we designed and tested the performance of the nano simulation structure of the host cell membrane. In order to develop this kind of simulated cell membrane, the researchers also designed a new step to make small artificial bubbles, which can be placed on the cell surface as cell receptors, and such polymer vesicles carrying water-soluble host receptors can be prepared by a mixture of two different block copolymers, which can be carried out in aqueous solution. Spontaneous assembly.
In general, Plasmodium can destroy the function of host red blood cells 48 hours after entering the body, and then it will continue to infect new red blood cells. In the infection stage, Plasmodium must bind to a special host cell receptor, while researchers have developed a nano cell membrane structure that can bind Plasmodium from the cell outflow, and then block its invasion into other uninfected cells.
In this study, the researchers used fluorescence and electron microscopy to detect the interaction between the nanocell membrane and Plasmodium. The researchers said that compared with the water-soluble cell receptor, the Nanosimulation structure can reduce the infection of Plasmodium by 100 times; in other words, in order to block the infection of Plasmodium, it needs to use the water-soluble receptor of 100 times concentration Completely blocked.
Finally, the researchers said that this study provides new research ideas and hopes for the later development of new alternative therapies and vaccines for malaria treatment. Because many other pathogens will also use the same cell receptor to attack at present, the new nano simulation technology developed by the researchers in this paper may help to treat other infectious diseases.